Lung mechanics and respiratory morbidities in school-age children born moderate-to-late preterm
| Autor: | Paulo A. F. Magalhães, Emilly C. N. Hora, Livia Barboza de Andrade, Fabianne M. N. A. Dantas, Emanuel Sarinho, José Ângelo Rizzo, Décio Medeiros Peixoto |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty School age child business.industry medicine.drug_class Lung mechanics Pulmonary function testing 03 medical and health sciences 0302 clinical medicine Increased risk 030225 pediatrics Bronchodilator Pediatrics Perinatology and Child Health medicine Late preterm Respiratory system business 030217 neurology & neurosurgery Lung function |
| Zdroj: | Pediatric Research. 91:1136-1140 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1038/s41390-021-01538-y |
| Popis: | Background Late and moderate prematurity may have an impact on pulmonary function during childhood. The present study aimed to investigate lung mechanics in school-age children born moderate-to-late preterm (MLPT). Methods Children aged 5-10 years were enrolled in this case-control study. Lung function and bronchodilator response were assessed by impulse oscillometry (IOS) at two hospital-based specialized clinics. A structured questionnaire was employed to assess respiratory morbidities. Results A total of 123 children was divided into two groups: case (MLPT) n = 52 and control (children born at term) n = 71. The results showed no difference between groups in mean baseline IOS variables: R5 0.80 ± 0.20 vs 0.82 ± 0.22 kPa/L/s, p = 0.594, R20 0.54 ± 0.13 vs 0.55 ± 0.13 kPa/L/s, p = 0.732, R5-R20 0.26 ± 0.12 vs 0.27 ± 0.15 kPa/L/s, p = 0.615, X5 -0.29 ± 0.01 vs -0.29 ± 0.1 kPa/L/s, p = 0.990, Fres 21.1 ± 3.3 vs 21.7 ± 3.1 L/s, p = 0.380, and AX 2.7 ± 3.36 vs 2.5 ± 1.31 kPa/L/s, p = 0.626. Bronchodilator response and the occurrence of respiratory morbidities after birth were also similar between groups. Conclusions This study found lung mechanics parameters to be similar in school-age children born MLPT and those born at term, suggesting that pulmonary plasticity continues to occur in children up to school age. Impact Late and moderate prematurity is associated with an increased risk of reduced pulmonary function during childhood. Follow-up reports in adolescents and adults born MLPT are scarce but have indicated pulmonary plasticity with normalization of airway function. Our results show that the lung function in school-age children born MLPT is similar to that of children born at term. |
| Databáze: | OpenAIRE |
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