CD30-Positive Anaplastic Large Cell Lymphoma (ALCL) of T-Cell Lineage in a 14-Month-Old Infant With Perinatally Acquired HIV-1 Infection
| Autor: | Joshua Z. Sickel, Ann W. Funkhouser, John S. Lambert, Philip J. Katzman |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
education.field_of_study
Pathology medicine.medical_specialty business.industry Large cell T cell Population Large-cell lymphoma Hematology medicine.disease Lymphoma medicine.anatomical_structure Oncology Giant cell hemic and lymphatic diseases Pediatrics Perinatology and Child Health Immunology medicine education business Anaplastic large-cell lymphoma Histiocyte |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 20:556-559 |
| ISSN: | 1077-4114 |
| DOI: | 10.1097/00043426-199811000-00009 |
| Popis: | Purpose CD30-positive anaplastic large cell lymphoma (ALCL) has been described in adults with HIV-1 infection but is extremely rare in HIV-1-infected infants and children. Patient and methods A 14-month-old girl with congenitally acquired HIV-1 infection presented with fever and a tender, erythematous, cystic mass on the right labium majorum. The mass was biopsied. Histologic examination and immunohistochemistry were performed. Results Histologic examination showed Touton-like giant cells resembling histiocytes and focally abundant neutrophils obscuring the lymphoid infiltrate. Immunocytochemistry revealed a CD30-positive ALCL of T-cell lineage. Conclusion Although non-Hodgkin's lymphoma is known to be associated with HIV-1 infection in children, large cell lymphomas of T-cell lineage are extremely rare in this population. Early diagnosis should be aggressively pursued in an HIV-1-infected child who presents with a fever and cutaneous mass. |
| Databáze: | OpenAIRE |
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