| Autor: |
Sehime Gulsun Temel, Mahmut Cerkez Ergoren, Izel Yilmaz, Ozel Yuruker, Havva Cobanogullari, Ozgur Tosun, Haluk Barbaros Oral, Nerin Nadir Bahceciler |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
The EuroBiotech Journal. 6:126-132 |
| ISSN: |
2564-615X |
| Popis: |
Objective: Allergic asthma is the most frequently observed subtype of individuals with asthma. The effects of serotonin plays in the pathophysiology of asthma has not been clearly determined. Thus, this study aimed to investigate the association between the 5HTR2C gene rs 6318 G>C polymorphism and allergic asthma in pediatric patients in Cyprus. Methods: This study included total number of 177 individuals with 118 control and 59 pediatric patients (43 atopic and 16 non-atopic asthma patient). A skin prick test was performed for each patient to confirm asthma diagnosis and to evaluate atopic status. Genotyping for the 5HTR2C was completed by Real Time-PCR analysis. Results: The genotype distribution frequencies were not in agreement with the Hardy-Weinberg Equilibrium in the patients’ group (p Discussion & Conclusion: Overall, despite the finding of no association between the 5HTR2C rs6318 C allele and childhood asthma, the current results indicated that there is a strong association between the 5HTR2C rs6318 C variant and childhood atopic asthma. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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