Synthesis, Crystal Structure, and Evaluation of Biologycal Activity of Novel Heterocyclic Derivative of 8-Hydroxyquinoline

Autor:	Taibi Ben Hadda, Youssef Ramli, Meriem Mequedade, Aboubaker El Hessni, Faisal A. Almalki, Mohamed Rbaa, Joel T. Mague, Brahim Lakhrissi, Inssaf Berkiks, Younes Lakhrissi
Rok vydání:	2020
Předmět:	chemistry.chemical_compound Chemistry Thio Organic synthesis Biological activity 8-Hydroxyquinoline Crystal structure Nuclear magnetic resonance spectroscopy Carbon-13 NMR Derivative (chemistry) Nuclear chemistry
Zdroj:	SSRN Electronic Journal.
ISSN:	1556-5068
DOI:	10.2139/ssrn.3589130
Popis:	In this study, a new derivative of 8-hydroxyquinoline has been synthesized, and characterized by 1H/13C NMR, IR, elemental analysis, and X-ray crystallography. The potential anti-anxiety, and anti-depressant effects of intraperitoneal administration of 5-(((2-hydroxy-ethyl) thio) methyl)quinolin-8-ol were evaluated using the behavioral tests: Open Field Test (OFT), Elevated Plus-Maze (EPM) test, and Forced Swim Test (FST).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4e42f1f6168d79d5e531b5f8adbd981f https://doi.org/10.2139/ssrn.3589130 Zobrazit plný text záznamu