Maternal and cord anti-SARS-CoV-2-spike IgG following COVID-19 vaccination vs. infection during pregnancy: a prospective study, Israel October 2021-March 2022

Autor: Raneen Abu Shqara, Maya Wolf, Susana Mikhail Mustafa, Inshirah Sgayer, Tikva Assulyn, Abdallah Abu Zraki, Nadine Askhar Majadla, Hagai Rechnitzer, Mona Shehadeh, Vered Fleisher Sheffer, Mor Bordeynik-Cohen, Orly Yakir, Lior Lowenstein, Eyal Sela, Michael Edelstein, Amiel Dror
Rok vydání: 2023
Předmět:
Zdroj: American Journal of Perinatology.
ISSN: 1098-8785
0735-1631
Popis: Objectives: Defining how pregnant women respond to SARS-CoV-2 infection and vaccination is critical to optimize vaccination strategies that protect mother and infant at the epidemic. This study aimed to compare Anti-SARS-CoV-2-spike IgG of vaccinated vs. infected women and to determine the optimal timing of maternal vaccination during pregnancy at the time of epidemic. Study design: We collected maternal/cord blood at delivery (October 2021-March 2022) and measured Anti-SARS-CoV-2-spike-IgG geometric mean concentrations (IgG-GMC), using a quantitative immunoassay. We compared groups according to timing and number of doses and correlated maternal and fetal IgG levels. We described the proportion of women with IgG-levels above the 150 AU/ml positivity threshold according to the timing of infection/vaccination and performed a sub-analysis for maternal IgG-GMC levels pre and during the Omicron wave. Results: We included 238 vaccinated women, 125 who received two doses and 113 three; and 48 unvaccinated infected women. All groups infected/vaccinated in the second or third-trimester had an IgG-GMC above the positivity threshold. Third-trimester vaccination (second/third dose) resulted in higher maternal and cord-blood IgG-GMC compared to the second-trimester (maternal-IgG:10232 vs. 4325 AU/mL,ptwo doses and their newborns had IgG-levels above the positivity threshold at all time points. In vaccinated-women, there were higher maternal IgG-GMC levels during the Omicron wave than pre-Omicron. Conclusions: At the time of epidemic, receiving an additional COVID-19 vaccine dose in the third-trimester resulted in a higher IgG-GMC compared to the second-trimester. Relatively higher levels of maternal and cord IgG-GMC were achieved following vaccination than infection. Women infected during or before the first-trimester might benefit from an additional third-trimester dose to prevent peripartum infection and to passively immunize their newborn. The higher levels of maternal IgG-GMC in the Omicron period are suggestive of hybrid immunity.
Databáze: OpenAIRE
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