Effect of methanolic extract of Dennettia tripetala (pepper fruit) on biomarkers of oxidative stress and lipid peroxidation in type 2 diabetic male wistar rats
| Autor: | Ude Victor Chibueze, Ugwudike Patrick, Agu Francis, Augustine Ndubuisi, Joachin Ezeokeke, Lilian Ndubuisi, Celestine Ani, Nwaeme Ogochukwu, Emeka Ugwuishi, Hector Obianyido, N Daniel, Sunday Njoba |
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| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Antioxidant medicine.medical_treatment Intraperitoneal injection Pharmacology medicine.disease_cause 01 natural sciences Applied Microbiology and Biotechnology Lipid peroxidation Glibenclamide chemistry.chemical_compound 010608 biotechnology Diabetes mellitus Genetics medicine Molecular Biology biology medicine.disease Streptozotocin chemistry Catalase biology.protein Agronomy and Crop Science Oxidative stress 010606 plant biology & botany Biotechnology medicine.drug |
| Zdroj: | African Journal of Biotechnology. 19:99-105 |
| ISSN: | 1684-5315 |
| Popis: | Oxidative stress resulting from chronic hyperglycemia in diabetes is due to high production of reactive oxygen species and/or a decrease in the antioxidant defense system activity. The study was designed to investigate the ameliorative effect of methanolic extract of Dennettia tripetala (DT) on oxidative stress and blood glucose level in type II diabetic male Wistar rats. Type II diabetes was induced by a single intraperitoneal injection of streptozotocin (40 mg/kg) after 2 weeks of 10% fructose diet. Twenty-five (25) rats were randomly divided into five groups, namely: 1 (normal control), 2 (negative control), 3 (10 mg/kg of glibenclamide), 4 (100 mg/kg of DT extract) and 5 (200 mg/kg of DT extract). The administration of the extract caused a significant decrease in blood glucose levels in all treatment groups. A significant (P |
| Databáze: | OpenAIRE |
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