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Background: Supportive supervision is one of five essential components of the WHO’s Reaching Every District strategy, an operational approach to reach 90%, immunization coverage. However, it is not mostly practiced based on the standard schedule because of capacity and low number of staffs in the health system. When it is practiced after long interval, it focuses more on inspection and finding lacunas. Taking into account the 54 universities in Ethiopia, the fundamental idea in this implementation science research is to test the feasibility and effectiveness of a Capacity Building and Mentorship Program in Immunization (CBMPI) by medical and health science colleges aimed at supplementing the current approach. Methods: This study applied a pre-post quasi experimental research design. The study included health workers of 30 health facilities (15 intervention and 15 control) followed for six months. To assess effectiveness on immunization coverage and a change in reaching every district strategy implementation difference in difference analysis was used to estimate the effect of the intervention implementation over time. Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) framework was used to evaluate the implementation process. Results: The findings of the study indicated that the intervention package has a statistically significant effect (P=0.0001) in the overall implementation of Reaching Every District (RED) outcomes. The difference in difference analysis also indicated that health facilities in the intervention district have shown a higher Penta III coverage (17.4%) and complete vaccination coverage (16.6%) that is attributable to the intervention package. Similarly, knowledge and skills of health workers improved significantly (P |
