ChemInform Abstract: An Efficient PEG-400 Mediated Catalyst Free Green Synthesis of 2-Amino-thiazoles from α-Diazoketones and Thiourea

Autor:	M. Baby Ramana, B. Hari Babu, K. Bala Murali Krishna, K. Vijay, N. Sharmila
Rok vydání:	2016
Předmět:	Solvent system PEG 400 chemistry.chemical_compound chemistry Thiourea Yield (chemistry) General Medicine Thiazole Combinatorial chemistry Catalysis
Zdroj:	ChemInform. 47
ISSN:	0931-7597
DOI:	10.1002/chin.201652263
Popis:	A simple and efficient method has been developed for the synthesis of 2-aminothiazoles from α-diazoketones using PEG-400 solvent system. This novel synthetic approach involves the reaction between thiourea and α-diazoketones in PEG-400 at 100 °C to yield the corresponding 2-aminothiazoles in good yields. The method is simple, rapid and generates thiazole derivatives in excellent yields without the use of any catalysts. This green protocol can be utilized for fast synthesis of various 2-aminothiazoles in good yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4e39d8d77ca1c61284ee31fafe140347 https://doi.org/10.1002/chin.201652263 Zobrazit plný text záznamu Plný text