Tandyukisin, a novel ketoaldehyde decalin derivative, produced by a marine sponge-derived Trichoderma harzianum
| Autor: | Naoko Inno, Reiko Tanaka, Takeshi Yamada, Takashi Kikuchi, Yoshihide Umebayashi, Yuki Mizutani, Maiko Kawashima |
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| Rok vydání: | 2014 |
| Předmět: |
biology
Strain (chemistry) Stereochemistry Organic Chemistry Absolute configuration Trichoderma harzianum biology.organism_classification Biochemistry chemistry.chemical_compound Sponge chemistry Decalin Drug Discovery Cytotoxicity Two-dimensional nuclear magnetic resonance spectroscopy Derivative (chemistry) |
| Zdroj: | Tetrahedron Letters. 55:662-664 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2013.11.107 |
| Popis: | Tandyukisin (1), a novel decalin derivative with an enolic β-ketoaldehyde, has been isolated from a strain of Trichoderma harzianum OUPS-111D-4 originally derived from the marine sponge Halichondria okadai, and its structure has been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques. In addition, the absolute configuration for 1 was established by the application of CD spectrum to the tribenzoate derivative. This compounds exhibited moderate cytotoxicity against human cancer cell lines. |
| Databáze: | OpenAIRE |
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