Investigation of the possible protective role of gallic acid on paraoxanase and arylesterase activities in livers of rats with acute alcohol intoxication
| Autor: | Güngör Kanbak, Mediha Canbek, Hakan Şentürk, Aysegul Oglakci, Gokhan Bayramoglu, Kazim Kartkaya |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Alcoholic liver disease Ethanol Antioxidant biology medicine.medical_treatment Clinical Biochemistry Paraoxonase Alcohol Cell Biology General Medicine medicine.disease Biochemistry Arylesterase chemistry.chemical_compound Endocrinology chemistry Internal medicine Lactate dehydrogenase medicine biology.protein Gallic acid |
| Zdroj: | Cell Biochemistry and Function. 31:208-213 |
| ISSN: | 0263-6484 |
| DOI: | 10.1002/cbf.2874 |
| Popis: | Gallic acid, a polyphenyl class natural product from gallnut and green tea, is known to be antioxidant, anti-inflammatory and radical scavenger. In this study, we aimed to investigate the possible protective effects of gallic acid on paraoxonase and arylesterase activities in liver exposed to acute alcohol intoxication. Paraoxonase and arylesterase activities in liver tissue and serum aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase levels were measured. Histological investigations were also made. In our study, we observed a significant increase of serum alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase activities, which are indicators of liver damage after acute ethanol consumption. Gallic acid therapy has significantly reduced the increase in these biomarkers, indicating a possible hepatoprotective effect of gallic acid. Ethanol consumption caused a significant decrease in liver paraoxonase activity (P |
| Databáze: | OpenAIRE |
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