Emergence of immunoblastic sarcoma in Waldenstrom's macroglobulinemia

Autor:	O. J. Martelo, A. F. Muhleman, P. E. Hurtubise, S. A. Leonhard
Rok vydání:	1980
Předmět:	Cancer Research Pathology medicine.medical_specialty business.industry Macroglobulinemia Malignant transformation medicine.anatomical_structure Oncology Plasmacytoid Lymphocytes Immunology Medicine Bone marrow Surface IgM business Immunoblastic sarcoma
Zdroj:	Cancer. 45:3102-3107
ISSN:	1097-0142 0008-543X
DOI:	10.1002/1097-0142(19800615)45:12<3102::aid-cncr2820451237>3.0.co;2-9
Popis:	A case involving a 65-year-old man with Waldenstrom's macroglobulinemia (WMG) which transformed into immunoblastic sarcoma is presented. Surface IgM (kappa) was demonstrated on the plasmacytoid lymphocytes of the bone marrow at presentation as well as on the less differentiated cells of the immunoblastic sarcoma. Serum IgM levels fell at the time that immunoblastic transformation occurred. This case illustrates the fact that a fall in serum paraprotein may herald a malignant transformation of WMG.
Databáze:	OpenAIRE
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