Intravitreal U75412E: A New Free Radical Scavenger

Autor:	Tim T. Lam, Richard G. Fiscella, Neal S. Peachey, Donald A. Gagliano, Richard M. Feist, Robert Dunn
Rok vydání:	1991
Předmět:	Chemotherapy medicine.medical_specialty Antioxidant Chemistry medicine.medical_treatment Radical Cell Pharmacology Free radical scavenger Surgery Lipid peroxidation chemistry.chemical_compound medicine.anatomical_structure Toxicity medicine Arachidonic acid
Zdroj:	Ophthalmic Surgery, Lasers and Imaging Retina. 22:740-744
ISSN:	2325-8179 2325-8160
DOI:	10.3928/1542-8877-19911201-11
Popis:	Free-radical-mediated tissue damage is thought to be involved in a multitude of ophthalmic pathologies. Therefore, drugs that scavenge free radicals may find wide clinical application. A new chemical class of antiinflammatory agents, the 21-aminosteroids, has been developed as free radical scavengers. These agents are thought to inhibit lipid peroxidation and prevent the release of free arachidonic acid from injured cell membranes. In the present study, we investigated the intraocular toxicity of one of the 21-aminosteroids, U75412E. Intravitreal doses of up to 0.1 mg of U75412E were nontoxic to rabbit ocular tissues.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4e1b5c19a517382029fae634f6c0c78c https://doi.org/10.3928/1542-8877-19911201-11 Zobrazit plný text záznamu