Modification of Biochemical Properties of Nitrosothiol by Fe3+ Cation: A Presumable Physiological Role
| Autor: | A. M. Dolgorukova, A. N. Osipov, V. A. Petrov, V. Yu. Titov, L. G. Ibragimova |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Iron Chelator biology Nitroso Compounds Chemistry Endogeny General Medicine General Biochemistry Genetics and Molecular Biology Ferrous 03 medical and health sciences Inhibitory potency 030104 developmental biology 0302 clinical medicine Biochemistry Catalase biology.protein Potency Hemoglobin 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 168:41-44 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | In the presence of Fe3+ cation, S-nitrosoglutathione (GSNO) loses the potency to inhibit catalase in the system containing hemoglobin (an NO trap) with iron chelator or -SH inhibitor (a “sulfhydric poison” Hg2+). In the absence of hemoglobin, the inhibitory potency is retained in both cases. These properties are characteristic of dinitrosyl-iron complexes containing ferrous iron and thiols (DNIC/RSH). Since the potency to inhibit catalase results from the presence of -NO group, its loss in the presence of hemoglobin relates probably to transfer of this group to hemoglobin. The nitrosothiols are relatively stable compounds, so their ability to release NO under the action of iron chelators, which is characteristic of DNIC/RSH, can have important physiological implications, because the role of such chelators can be played by some endogenous agents as well. Thus, release of NO from the donor compounds can be controlled and regulated. Probably, the agents such as nitrosothiol+Fe3+ are the major constituents in the pool of nitroso compounds. |
| Databáze: | OpenAIRE |
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