Increased anti-Epstein-Barr virus antibodies in epidermotropic cutaneous T-cell lymphoma: a study of 64 patients
| Autor: | P. Litoux, Jean-Michel Nguyen, S. Billaudel, Brigitte Dréno, C. Mollat, O. Jumbou |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Mycosis fungoides
Pathology medicine.medical_specialty biology business.industry Cutaneous T-cell lymphoma Dermatology medicine.disease medicine.disease_cause Epstein–Barr virus Peripheral T-cell lymphoma Serology Lymphoma Antigen hemic and lymphatic diseases Immunology medicine biology.protein Antibody business |
| Zdroj: | British Journal of Dermatology. 136:212-216 |
| ISSN: | 0007-0963 |
| DOI: | 10.1046/j.1365-2133.1997.d01-1171.x |
| Popis: | Epstein-Barr virus (EBV) is often associated with non-Hodgkin's T-cell lymphomas and has recently been found in the lesions of mycosis fungoides and Sezary syndrome. We sought to determine whether the anti-EBV antibody profile was disturbed in mycosis fungoides and Sezary syndrome and whether there are particular profiles characteristic of disease stage. Anti-EBV antibodies (anti-VCA, -EA and -EBNA) were studied in the sera of 64 patients. An immunoenzymatic technique was used, and the results were compared with the same number of age- and sex-matched healthy controls. Patients with mycosis fungoides and Sezary syndrome developed higher anti-VCA antibody titres (median 1200) than controls (median 320). Thirty-seven patients had anti-VCA > or = 1200 vs. 19 controls (P < 0.01). These elevated anti-VCA antibody titres were associated with positive EA in 19 patients versus three controls. No differences were found between the illness stages. Anti-EBV antibodies were most often found in mycosis fungoides and Sezary syndrome when the serological profile was similar to that of cellular immune deficiencies and EBV-related non-Hodgkin's lymphoma. EBV could be involved, either directly on lymphocytes or, more likely, indirectly by chronic antigenic stimulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text