| Autor: |
Giulio Cesareo, Laura Giorgia Rizzi, Patrick Soon-Shiong, Gabriele Babini, Ivana Palucci, Flavio De Maio, Giovanni Delogu, Maurizio Sanguinetti, Valentina Palmieri, Alessandro Salustri, Alberto Augello, Giordano Perini, Massimiliano Papi, Michela Sali, Marco De Spirito |
| Rok vydání: |
2020 |
| Předmět: |
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| DOI: |
10.1101/2020.09.16.20194316 |
| Popis: |
Recent advancements in bidimensional nanoparticles such as Graphene nanoplatelets (G) and the derivative Graphene oxide (GO) have the potential to meet the need for highly functional personal protective equipment (PPE) that confers increased protection against SARS-CoV-2 infection and the spread COVID-19. The ability of G and GO to interact with and bind microorganisms as well as RNA and DNA provides an opportunity to develop engineered textiles for use in PPE. The face masks widely used in health care and other high-risk settings for COVID transmission provide only a physical barrier that decreases likelihood of infection and do not inactivate the virus. Here, we show pre-incubation of viral particles with free GO inhibits SARS-CoV-2 infection of VERO cells. Highly relevant to PPE materials, when either polyurethane or cotton material was loaded with G or GO and culture medium containing SARS-CoV-2 viral particles either filtered through or incubated with the functionalized materials, the infectivity of the medium was nearly completely inhibited. The findings presented here constitute an important nanomaterials-based strategy to significantly increase face mask and other PPE efficacy in protection against the SARS-CoV-2 virus and COVID-19 that may be applicable to additional anti-SARS-CoV-2 measures including water filtration, air purification, and diagnostics.One Sentence SummaryCotton and polyurethane materials functionalized with bidimensional Graphene nanoplatelets trap SARS-CoV-2 and have the potential to reduce spread of COVID-19. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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