Citric acid crosslinked carboxymethylcellulose-polyvinyl alcohol hydrogel films for extended release of water soluble basic drugs
| Autor: | Kailas K. Mali, Safina Ismail Mulla, Remeth J. Dias, Vishwajeet S. Ghorpade |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
integumentary system
Chemistry technology industry and agriculture Pharmaceutical Science Biomaterial Alcohol macromolecular substances 02 engineering and technology 021001 nanoscience & nanotechnology complex mixtures 030226 pharmacology & pharmacy law.invention 03 medical and health sciences chemistry.chemical_compound Gentamicin Sulfate 0302 clinical medicine Water soluble Magazine Chemical engineering law Ultimate tensile strength 0210 nano-technology Thermal analysis Citric acid |
| Zdroj: | Journal of Drug Delivery Science and Technology. 52:421-430 |
| ISSN: | 1773-2247 |
| DOI: | 10.1016/j.jddst.2019.05.013 |
| Popis: | The aim of present work was to develop carboxymethylcellulose (CMC)-polyvinyl alcohol (PVA) hydrogel films for extended delivery of water soluble basic drug, using citric acid (CA) as a cheap and non-toxic crosslinking agent. Gentamicin sulfate (GTM) was used as a model drug. The hydrogel films were evaluated for carboxyl content, tensile strength, swellability, drug loading and release, hemocompatibility and characterized by 13C-CP-MAS NMR, ATR-FTIR and thermal analysis (TGA and DSC). The instrumental analysis helped to confirm the formation of ester crosslinks. CMC-PVA hydrogel films exhibited greater carboxyl content, tensile strength and swellability than the pure CMC hydrogel films. The GTM loading increased with an increase in the amount of PVA in the hydrogel films. The CMC-PVA hydrogel films showed propensity to extend the release of GTM above 24 h. Hemolysis assay revealed the hemocompatible nature of the hydrogel films. Altogether, the CMC-PVA hydrogel films can be envisioned as promising biomaterial for the delivery of water soluble basic drugs. |
| Databáze: | OpenAIRE |
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