3-(Hetarylamino)- and 3-[(hetarylmethyl)amino]-isoquinolin-1(2H)-ones

Autor:	Vladimir A. Kovtunenko, Andrei A. Tolmachev, R. M. Gutsul, L. M. Potikha
Rok vydání:	2010
Předmět:	Hydrolysis chemistry.chemical_compound Chemistry Organic Chemistry Side reaction Organic chemistry Benzoic acid
Zdroj:	Chemistry of Heterocyclic Compounds. 46:457-467
ISSN:	1573-8353 0009-3122
DOI:	10.1007/s10593-010-0531-0
Popis:	The reaction of 2-(cyanomethyl)benzoic acid with amines RNH2 (R = Ar, Het, CH2Ar, CH2Het) leads to the formation of the corresponding 3-NHR-isoquinolin-1(2H)-ones. When R = CH2Ar and CH2Het, there is a side reaction involving hydrolysis of the hydrolytically-unstable intermediates, derivatives of 2-(2-amino-2-iminoethyl)benzoic acid, leading to 2-R-isoquinoline-1,3(2H,4H)-diones.
Databáze:	OpenAIRE
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