Recurrence-free survival after total thyroidectomy and lobectomy in patients with papillary thyroid microcarcinoma
| Autor: | Catherine F. Sinclair, M. Van Gerwen, Eric M. Genden, E Lee, Emanuela Taioli, Mathilda Alsen |
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| Rok vydání: | 2020 |
| Předmět: |
Total thyroidectomy
medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Incidence (epidemiology) medicine.medical_treatment Thyroidectomy 030209 endocrinology & metabolism medicine.disease Confidence interval Surgery 03 medical and health sciences 0302 clinical medicine Endocrinology 030220 oncology & carcinogenesis Meta-analysis medicine In patient Clinical significance business Thyroid cancer |
| Zdroj: | Journal of Endocrinological Investigation. 44:725-734 |
| ISSN: | 1720-8386 |
| Popis: | The incidence of papillary thyroid microcarcinoma is increasing. We evaluated the recurrence-free survival following total thyroidectomy and lobectomy to identify the optimal surgical choice. A meta-analysis was performed using the National Library of Medicine and the National Institutes of Health PubMed database to identify eligible studies. Summary 5- and 10-year RFS estimates after TT versus LT were calculated using random effects models. The literature search yielded 1117 studies (1990–2019). Nine studies met the inclusion criteria comprising 10,186 total thyroidectomy and 11,408 lobectomy patients. The 5-year recurrence-free survival was 98% [95% confidence interval (CI) 97–99%] after total thyroidectomy and 97% (95% CI 96–99%) after lobectomy, based on eight studies (9421 total thyroidectomy and 11,283 lobectomy patients); the 10-year recurrence-free survival was 95% (95% CI 92–98%) after total thyroidectomy and 92% (95% CI 86–96%) after lobectomy, based on eight studies (total thyroidectomy = 10,100, lobectomy = 11,389 patients). The present meta-analysis demonstrates excellent, long-term recurrence-free survival following both total thyroidectomy and lobectomy surgery in patients with papillary thyroid microcarcinoma. The analysis also suggests that patients undergoing total thyroidectomy trended toward a slightly better long-term 10-year recurrence-free survival in comparison to patients undergoing lobectomy, a finding of potential, clinical significance in the management decision-making process. |
| Databáze: | OpenAIRE |
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