Détection par IRM des récidives locales du cancer de prostate après traitement par ultrasons focalisés de haute intensité (HIFU) transrectaux : étude préliminaire
| Autor: | Albert Gelet, Denis Lyonnet, A. Ben Cheikh, Florence Mège-Lechevallier, N. Girouin, Olivier Rouvière, P. Ryon-Taponnier, Jean-Yves Chapelon |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Gynecology
medicine.medical_specialty Prostate biopsy Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Cancer Odds ratio medicine.disease Confidence interval Prostate cancer medicine.anatomical_structure Prostate Hifu treatment Biopsy medicine Radiology Nuclear Medicine and imaging business Nuclear medicine |
| Zdroj: | Journal de Radiologie. 89:571-577 |
| ISSN: | 0221-0363 |
| Popis: | Resume MR detection of local prostate cancer recurrence after transrectal highintensity focused US treatment: preliminary results. J Radiol 2008;89:571-7 Purpose. To assess T2W and dynamic: contrast-enhanced (DCE) MR imaging in the detection of local tumor recurrence after transrectal high-intensity focused US (HIFU) treatment. Materials and methods. Fifteen patients treated by HIFU for prostate cancer were referred for MR due to biological evidence of tumor recurrence. Axial, sagittal and coronal T2W images and DCE images (12 3-mm thick axial images, temporal resolution: 15 seconds) were obtained first. Transrectal biopsies were then obtained under US guidance. MR findings were compared to biopsy results for 10 prostate sectors. Results. Biopsies demonstrated tumor recurrence in 13/15 patients (23/ 108 sectors). On T2W images, the treated prostate tissue was diffusely hypointense which interfered with interpretation. Three patients (5 sectors) had suspicious areas of T2W signal abnormality and 15 patients (29 sectors) had suspicious areas on DCE scans. An analysis per sector for T2W and DCE imaging showed sensitivity, specificity, positive predictive and negative predictive values respectively of 0.13, 0.98, 0.6 and 0.81 and 0.70, 0.85, 0.55 and 0.91. DCE MR was strongly predictive of positive biopsy results (Odds ratio: 12.8 (95% confidence interval: 4.4-37.3)) whereas T2W imaging was not (Odds ratio: 4.0 (95% confidence interval: 0.5-30)). Conclusion. MR, especially DCE MR, is promising for the detection and localization of local prostate cancer recurrence after transrectal HIFU treatment. Objectif. Evaluer l’IRM T2 et dynamique dans la detection des |
| Databáze: | OpenAIRE |
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