| Popis: |
The larger part of the systemic hemodynamic resistance is located in the microcirculation. The microcirculatory networks, especially its arteriolar and capillary components, are subjected to angiogenesis in relation to the activation of the HIF-VEGF-NO pathways. In the present chapter we report experiments performed in young and adult spontaneously hypertensive rats maintained for several weeks under chronic hypoxic conditions. Chronic hypoxia resulted in activation of VEGF-induced angiogenesis, increases in myocardial and skeletal muscle capillary density, and normalization of arterial blood pressure in both young prehypertensive rats and old rats with established hypertension. |
