Review : Apoptosis: regulation and relevance to toxicology
| Autor: | C. E. Sarraf, Malcolm R. Alison |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
0301 basic medicine
Programmed cell death 030102 biochemistry & molecular biology Cell growth Health Toxicology and Mutagenesis Cell General Medicine Biology Toxicology Cell biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.anatomical_structure chemistry Apoptosis 030220 oncology & carcinogenesis medicine Gene Intracellular DNA Therapeutic strategy |
| Zdroj: | Human & Experimental Toxicology. 14:234-247 |
| ISSN: | 1477-0903 0960-3271 |
| DOI: | 10.1177/096032719501400302 |
| Popis: | 1 Apopotosis is a remarkably stereotyped morphological event across all tissues in response to a vast array of dam aging agents. 2 Our very existence depends upon a willing exchange of old life for new: apoptotic cell death is our guardian and saviour from genetic damage. 3 There is a close link between cell proliferation and apoptosis: When a cell picks up the machinery to prolifer ate it also acquires an abort pathway - 'better dead than wrong'. 4 A wide variety of highly conserved genes have been implicated in triggering apoptosis. 5 The release of DNA loops from the nuclear scaffold is a more crucial intracellular event than DNA 'laddering' in apoptotic cells. 6 The manipulation of apoptotic rates in many of the common diseases in man will be a major therapeutic strategy in the future. |
| Databáze: | OpenAIRE |
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