THE EFFECT OF M&B 22,948 (AN ORALLY ABSORBED MAST CELL STABILISER) ON EXERCISE INDUCED ASTHMA IN CHILDREN

Autor:	Y. Yeang, J.O. Warner, J. Reiser
Rok vydání:	1985
Předmět:	Mast cell stabiliser Exercise-induced asthma business.industry Pediatrics Perinatology and Child Health Immunology Sodium cromoglycate Medicine Pharmacology business medicine.disease Placebo Asthma
Zdroj:	Pediatric Research. 19:1098-1098
ISSN:	1530-0447 0031-3998
DOI:	10.1203/00006450-198510000-00177
Popis:	Since the introduction of sodium cromoglycate, attempts have been made to develop a drug with similar activity when taken orally. M&B 22,948 is an orally absorbed mast cell stabiliser which has previously been shown to block exercise induced asthma in adults. We conducted a trial in which 15 children with asthma each undertook three exercise challenges. They were pretreated with either M&B 22,948 or placebo, given double-blind, in randomly allocated order, prior to the second and third challenges. Our results failed to show a protective effect of M&B 22,948 against exercise induced asthma but the possible reasons for the discrepancy with the previous trial will be discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4dcf141a0f6337b7788d35b05c39c673 https://doi.org/10.1203/00006450-198510000-00177 Zobrazit plný text záznamu