Anticataleptogenic effect of delta-sleep inducing peptide and its effect on brain monoamine oxidase of rats genetically predisposed to catalepsy
| Autor: | T. A. Alekhina, V. G. Kolpakov, N. N. Voitenko |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Chemistry Monoamine oxidase Deamination Peptide General Medicine Catalepsy medicine.disease General Biochemistry Genetics and Molecular Biology Endocrinology Biochemistry Dopamine Internal medicine Genetic predisposition medicine Delta sleep-inducing peptide Monoamine oxidase B medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 110:1261-1264 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00840301 |
| Popis: | Rats with genetic susceptibility to catalepsy (GC strain) were compared with Wistar rats (W). After an intraperitoneal administration of 120 micrograms/100 g delta sleep-inducing peptide (DSIP) in GC rats the duration of cataleptic freezing was shortened (13.8 +/- 9.5 sec against 27.2 +/- 7.5 sec in control). MAO-B activity decreased due to DSIP administration both in GC and W rats. It is hypothesized that the DSIP effect MAO-B in GC rats may correct the lost MAO-A function in deamination of dopamine, a common MAO-A and MAO-B substrate, and the dopaminergic neurotransmission in catalepsy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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