Synthesis of a Valen Schiff-base bismuth(III) complex and its thermokinetic studies on the growth metabolism of S. pombe

Autor:	Li-Juan Ye, Fan-Hua Zeng, Qu Sha, Qiang-Guo Li, Rou Zou, Jian-Hong Jiang, Zhao-Biao Mou, Xu Li, Chuan-Hua Li
Rok vydání:	2020
Předmět:	Schiff base Ligand Molar conductivity chemistry.chemical_element 02 engineering and technology Metabolism 021001 nanoscience & nanotechnology Condensed Matter Physics Mass spectrometry 01 natural sciences 010406 physical chemistry 0104 chemical sciences Bismuth chemistry.chemical_compound chemistry Physical and Theoretical Chemistry 0210 nano-technology IC50 Inhibitory effect Nuclear chemistry
Zdroj:	Journal of Thermal Analysis and Calorimetry. 142:2341-2349
ISSN:	1588-2926 1388-6150
DOI:	10.1007/s10973-020-09269-8
Popis:	A Valen Schiff-base ligand [1,5-bis(2-hydroxy-3-methoxybenzylidene)thiocarbonohydrazide] and its bismuth(III) complex were synthesized. The compositions and structures of two compounds were characterized by elemental analysis, spectrometry (1HNMR, MS, FT-IR, and UV-visible), chemical analysis, molar conductivity, and TG–DTA analysis. The results showed that the molecular formula of Schiff base and its bismuth(III) complex was C17H18O4N4S (abbreviated as H2L, L = C17H16O4N4S) and [Bi(C17H16O4N4S)Cl·H2O] (abbreviated as [Bi(L)Cl·H2O]), respectively. Furthermore, the thermokinetic properties of the action of Schiff base and its bismuth(III) complex on the growth metabolism of S. pombe were studied by bio-microcalorimetry at 305.15 K. The growth rate constant (k), maximum heat power, generation time, inhibition ratio (I) and half inhibition concentration (IC50), and their quantitative relationship with the concentration were calculated, respectively. Experimental results indicated that both Schiff base and its bismuth(III) complex could inhibit the growth of S. pombe, but the inhibitory effect of Schiff base was stronger than that of the complex. The half inhibition concentrations of Schiff base and its bismuth(III) complex were found to be 4.17 × 10−3 mol L−1 and 6.13 × 10−3 mol L−1, respectively.
Databáze:	OpenAIRE
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