The impact of Cannabis in Schizophrenia: Pafip Three-year Longitudinal Study on Outcome and Functionality After a First Episode of Psychosis

Autor:	R. Medina Blanco, M. Gómez Revuelta, M. Juncal Ruiz, L. Sánchez Blanco, B. Crespo Facorro, R. Gutierrez Martin, R. Landera Rodríguez, I. Madrazo del Río Hortega, M. Fernández Rodríguez, D. Abejas Díez, O. Porta Olivares
Rok vydání:	2017
Předmět:	First episode medicine.medical_specialty Psychosis Longitudinal study biology biology.organism_classification medicine.disease Psychiatry and Mental health Schizophrenia Intervention (counseling) medicine In patient Cannabis Age of onset Psychiatry Psychology
Zdroj:	European Psychiatry. 41:S136-S137
ISSN:	1778-3585 0924-9338
DOI:	10.1016/j.eurpsy.2017.01.1962
Popis:	IntroductionThe association between cannabis and psychosis makes crucial the intervention on cannabis use disorder at first episodes of psychosis (FEP), especially among young population. In this group of patients, the harmful potential of cannabis is more evident by its influence on neurodevelopment. However, the nature of the association cannabis-psychosis is not clearly described. It seems to represent a mediating factor for an increased risk of psychosis in healthy and high-risk populations, determining an earlier age of onset and worsening long term outcome.ObjectivesTo assess the impact of cannabis in terms of functional and clinical prognosis in patients recruited after a FEP.Material and methodsPAFIP is an early intervention program for early stages of psychosis. One hundred and sixty-three were included, followed-up at regular intervals of six months for three years with administration of clinical and functional scales (BPRS, SAPS, SANS, CDRS, GAF and Drake). Patients were divided into three groups: (1) those non-users neither before the onset nor during follow-up (nn) PEP, (2) consumers before the FEP and during follow-up (ss) and (3) consumers before the FEP that gave up consumption during follow-up (sn).ResultsNo statistically significant differences were observed in terms of functionality at three-year follow-up endpoint but a trend to a better-preserved functionality in the sn group. The sn group presented lower scores in scales for positive symptoms with respect to the comparison groups.ConclusionsThe interruption in cannabis use may have a beneficial effect on short-term clinical prognosis and functionality on long term.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Databáze:	OpenAIRE
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