Highly stretchable and tough pH-sensitive hydrogels with reversible swelling and recoverable deformation
| Autor: | Xue Jiao Liu, Xiu Yan Ren, Bao Yuan Zhang, Guanghui Gao, Hai Qiang Li, Ya Jun Wang, Shuang Guan |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
General Chemical Engineering macromolecular substances 02 engineering and technology 010402 general chemistry complex mixtures 01 natural sciences Tissue engineering PEG ratio Polymer chemistry medicine chemistry.chemical_classification technology industry and agriculture General Chemistry Polymer 021001 nanoscience & nanotechnology 0104 chemical sciences Compressive strength chemistry Chemical engineering Drug delivery Self-healing hydrogels Deformation (engineering) Swelling medicine.symptom 0210 nano-technology |
| Zdroj: | RSC Advances. 6:4850-4857 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c5ra24414e |
| Popis: | Stimuli-responsive hydrogels are becoming increasingly important for controlled drug delivery, biosensing, and tissue engineering. However, few pH-sensitive hydrogels with good mechanical property have been extensively reported. In this investigation, we reported the preparation of extremely stretchable and tough pH-sensitive hydrogels by introducing a linear polysaccharide-agar into the poly(acrylamide-co-acrylic acid) (P(AM-co-AA)) network and using diacrylated PEG (PEGDA) as a chemical crosslinker based on a simultaneous interpenetrating polymer networks (IPN) structure. It was found that longer PEGDA chains would lead to the obvious increase in swelling ratio and the stretchability of hydrogels. Moreover, the content of agar, the crosslinker concentration and the pH of the external environment would significantly affect the mechanical characteristics of the hydrogels. The compression strength and dissipated energy could reach 4.56 MPa and 0.56 MJ m−3 under the deformation of 85%, respectively. Also, hydrogels exhibited excellent reversible swelling and recoverable deformation. The improved mechanical properties enable the pH-sensitive hydrogels to be potential candidates in the field of load-bearing soft tissues. |
| Databáze: | OpenAIRE |
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