Amplifications of DNA primase 1 (PRIM1) in human osteosarcoma

Autor:	Pierre Russo, Jean-Marie Leclerc, George-Etienne Rivard, Hugo Hamel, Martin A. Champagne, Mark L. Bernstein, Emile Levy, Wagner V. Yotov
Rok vydání:	1999
Předmět:	Genetics Cancer Research Differential display medicine.diagnostic_test Cancer Biology Amplicon medicine.disease Molecular biology medicine Osteosarcoma Primase Gene Southern blot Fluorescence in situ hybridization
Zdroj:	Genes, Chromosomes and Cancer. 26:62-69
ISSN:	1098-2264 1045-2257
DOI:	10.1002/(sici)1098-2264(199909)26:1<62::aid-gcc9>3.0.co;2-f
Popis:	We studied the involvement of PRIM1 in osteosarcoma by differential display, Northern and Southern hybridization, as well as fluorescence in situ hybridization (FISH) on interphase nuclei. In total, 22 pediatric oncology specimens were tested. PRIM1 was found to be amplified in 41% of the samples. PRIM1 is coamplified with the core 12q13 amplicon genes CDK4, SAS, and OS9, and was physically mapped very close to them. PRIM1 is therefore a new candidate for the role of a major target gene of 12q13 amplifications in human cancers. Genes Chromosomes Cancer 26:62-69, 1999.
Databáze:	OpenAIRE
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