ChemInform Abstract: Synthesis of Novel 9-Aryl and Heteroarylpurine Derivatives via Copper Mediated Coupling Reaction

Autor:	L. Morellato, Valérie Huteau, Sylvie Pochet
Rok vydání:	2014
Předmět:	Steric effects chemistry.chemical_compound chemistry Aryl Biological property Copper mediated Organic chemistry Purine derivative chemistry.chemical_element General Medicine Copper Coupling reaction Adenine derivatives
Zdroj:	ChemInform. 45
ISSN:	0931-7597
DOI:	10.1002/chin.201430171
Popis:	A series of 9-(hetero)arylpurine derivatives has been prepared through N-arylation of 6-chloropurine with boronic acids in the presence of copper(II) acetate. Screening reaction conditions in terms of bases and solvents led to the successful coupling of a series of sterically demanding (hetero)arylboronic acids, never described so far. The coupling products were next readily converted into the target adenine derivatives. The described procedure provides easy access to original fragments for screening applications. Moreover these 9-aryl-6-chloropurine derivatives might be useful as intermediates for the preparation of purine derivatives with potential biological properties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4dabb4fb4fb8dcb3b83f802368a7966e https://doi.org/10.1002/chin.201430171 Zobrazit plný text záznamu Plný text