Salvage vinorelbine (VNR) in the 2nd to 4th line setting in advanced non-small cell lung cancer (NSCLC): A retrospective review at the Fox Chase Cancer Center (FCCC)

Autor:	J. G. Devlin, Corey J. Langer
Rok vydání:	2006
Předmět:	Oncology Cancer Research Retrospective review medicine.medical_specialty business.industry Salvage treatment Cancer non-small cell lung cancer (NSCLC) medicine.disease Vinorelbine Minimal activity Internal medicine medicine business medicine.drug
Zdroj:	Journal of Clinical Oncology. 24:17072-17072
ISSN:	1527-7755 0732-183X
Popis:	17072 Background: Published literature has demonstrated minimal activity for VNR in the salvage treatment of NSCLC, with response rates of only 0.8% (Fossella, et al, JCO 2000; 18(12), 2354–2362). However, in our clinical experience, we have observed a number of patients (pts) with clinical benefit. Methods: Retrospective evaluation was performed of all pts with NSCLC who had received VNR at FCCC from 6/02–6/05 in the salvage setting. Pts were evaluable if full medical records (including radiographic imaging for disease assessment) were available, had received ≥2 cycles of VNR, and had advanced, recurrent or metastatic NSCLC. Primary endpoint was response rate (RR); secondary endpoints included safety, median overall survival (OS), and median time to progression (TTP). Results: 52 pts were included, 28 pts were ultimately evaluable (13 pts received [Table: see text]
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4d9d2bd11b5bc78bca0d3e6070ad8fd1 https://doi.org/10.1200/jco.2006.24.18_suppl.17072 Zobrazit plný text záznamu