Recruitment of Smooth Muscle Cells and Intercellular Calcium Waves during Arterial Vasomotion

Autor:	Michèle Koenigsberger, Jean-Louis Bény, Jean-Jacques Meister, Mathieu Lamboley, Dominique Seppey, Roger Sauser
Rok vydání:	2009
Předmět:	medicine.medical_specialty Endothelium Chemistry Natural property Vasomotion Anatomy musculoskeletal system medicine.anatomical_structure Endocrinology Smooth muscle Internal medicine cardiovascular system medicine Calcium Waves tissues Phenylephrine Intracellular Cytosolic calcium medicine.drug
Zdroj:	IFMBE Proceedings ISBN: 9783642038815
DOI:	10.1007/978-3-642-03882-2_112
Popis:	Vasomotion is a natural property of small arteries and arterioles. Vasomotion consists in cyclic diameter variations, which are induced by synchronous contractions of the smooth muscle cells (SMCs) present in the arterial wall. These contractions have been shown to be due to an increase in the SMCs cytosolic calcium concentration. The present study was performed on rat mesenteric arterial strips. The first part investigated the response of SMCs under different concentrations of phenylephrine (PE), a vasoconstrictor, with an emphasis on the synchronization of SMCs in endothelium denuded strips. We observed that the recruitment of the SMCs increased with the PE concentration and vasomotion appeared only when a sufficient number of SMCs were recruited and synchronized.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4d9befe760481b8eddfd0a381e23035b https://doi.org/10.1007/978-3-642-03882-2_112 Zobrazit plný text záznamu