Circadian variation of granulocyte colony stimulating factor levels in man
Autor: | Hans-Georg Eichler, Oswald Wagner, Bernd Jilma, Nicole Hergovich, P. Bauer, Petra Stohlawetz |
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Rok vydání: | 1999 |
Předmět: |
medicine.medical_specialty
medicine.drug_class medicine.medical_treatment Diurnal temperature variation Hematology Biology Granulocyte colony-stimulating factor Cytokine Endocrinology medicine.anatomical_structure Internal medicine Blood plasma medicine Corticosteroid Circadian rhythm Bone marrow Hydrocortisone medicine.drug |
Zdroj: | British Journal of Haematology. 106:368-370 |
ISSN: | 0007-1048 |
DOI: | 10.1046/j.1365-2141.1999.01543.x |
Popis: | Glucocorticoids dose-dependently increase plasma levels of granulocyte colony stimulating factor (G-CSF). Based on the marked circadian rhythm of cortisol levels, we hypothesized that plasma levels of G-CSF may also show a diurnal rhythm. A prospective study was conducted in 12 healthy young volunteers. Blood samples were obtained every 2 h over 24 h. G-CSF levels averaged 18.0 ng/l (CI 13. 1-22.9) at 8.00 am, increased continuously and reached peak values at 10.00 p.m. Individual harmonic regression analysis showed a clear circadian rhythm. The individual differences between nadir and peak levels averaged 54% (CI 43-65%). This pronounced diurnal rhythm of G-CSF levels may help understand the circadian changes in circulating stem cells, bone marrow DNA synthesis, or bone marrow toxicity induced by some chemotherapeutic agents. |
Databáze: | OpenAIRE |
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