Steady-State Mobilization of Peripheral Blood Progenitor Cells by Cytokines Alone in Patients with Solid Tumors or Hematological Malignancies

Autor:	C.C. Löliger, C. Rauhöft, P. Kühnl, W. Zeller, A.R. Zander, H. Renges, W Krüger, R. Erttmann, N. Fuchs, Nicolaus Kröger, K. Gutensohn, H. T. Hassan, B Rüssmann
Rok vydání:	1999
Předmět:	Mobilization business.industry medicine.medical_treatment Hematology Peripheral blood Endothelial stem cell Haematopoiesis Cytokine Immunology Immunology and Allergy Medicine Stem cell Progenitor cell business Progenitor
Zdroj:	Transfusion Medicine and Hemotherapy. 26:85-90
ISSN:	1660-3818 1660-3796
Popis:	Cytokines are involved in hematopoiesis and cell growth regulation. Many cytokines have the property of increasing the number of hematopoietic progenitor cells circulating in peripheral blood. Since it has been shown that peripheral blood progenitor support after myeloablative therapy resulted in a faster engraftment than after autologous bone marrow support, recent effort is focusing on optimizing stem cell harvest by different cytokines, cytokine combination, or evaluation of dose and schedule dependencies. One of the first cytokines shown to mobilize stem cells within peripheral blood was the granulocyte-stimulating factor (G-CSF). This review is focusing on the current state of cytokine-induced mobilization of stem cells in patients with hematological malignancies or solid tumors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4d97251d56affa4aa45ef91d9321bbe5 https://doi.org/10.1159/000053469 Zobrazit plný text záznamu