Structural alterations of rat erythrocytes induced by phosphacol poisoning
| Autor: | M. S. Dubrovnik, V. B. Prozorovskii, V. G. Skopichev, V. V. Petrov |
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| Rok vydání: | 1995 |
| Předmět: |
Phosphacol
medicine.medical_specialty Alkalosis Chemistry General Medicine medicine.disease Artificial respiration General Biochemistry Genetics and Molecular Biology Endocrinology Tissue acidosis Biochemistry Internal medicine Hyperventilation medicine medicine.symptom Blood ph Lung ventilation Acidosis |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 119:500-503 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf02543441 |
| Popis: | Nembutal-anesthetized rats under conditions of artificial respiration received intramuscular injections of phosphacol in doses equal to 0.5, 5, and 50 LD50. The lung ventilation per se induced blood changes typical of hyperventilation alkalosis. Poisoned animals showed the development of dose-dependent tissue acidosis. At a later stage of poisoning (2 hours) a high phosphacol dose induced decompensated acidosis, which caused the death of some animals. Electron microscopy revealed that the previously described rat erythrocyte deformation coincides in time with the changes of cytoskeleton content and depends on the dose of phosphacol but not on the blood pH. |
| Databáze: | OpenAIRE |
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