Zinc Finger Protein 202: A new candidate gene for ischemic heart disease
| Autor: | Rolf Steffensen, Peter Schnohr, Ruth Frikke-Schmidt, Maria C. A. Stene, Børge G. Nordestgaard, Anne Tybjærg-Hansen |
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| Rok vydání: | 2006 |
| Předmět: |
Candidate gene
medicine.medical_specialty education.field_of_study biology business.industry Hazard ratio Population Case-control study ZNF202 medicine.disease Endocrinology Internal medicine Cardiology medicine biology.protein Myocardial infarction Risk factor Cardiology and Cardiovascular Medicine Prospective cohort study business education |
| Zdroj: | Atherosclerosis. 188:43-50 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2005.10.014 |
| Popis: | Objective Zinc Finger Protein 202 (ZNF202) is a transcriptional repressor of genes affecting the vascular endothelium as well as lipid metabolism. A phenotype associated with genetic variation in ZNF202 is presently unknown. We tested the hypothesis that a common variant in ZNF202 , A154V, predicts risk of ischemic heart disease (IHD), myocardial infarction (MI), and ischemic cerebrovascular disease (ICVD). Methods and results We conducted a prospective study of more than 9000 individuals from the general population with 24 years follow-up. In women, age-adjusted hazard ratios in heterozygotes and homozygotes versus non-carriers were 1.2 (95% CI: 1.0–1.5, P =0.04) and 1.5 (1.1–2.1, P =0.007) for IHD, 1.5 (1.1–2.1; P =0.01) and 1.7 (1.1–2.8, P =0.02) for MI, and 1.3 (1.0–1.8, P =0.07) and 1.3 (0.8–2.1; P =0.33) for ICVD. Adjustments for lipids and lipoproteins did not alter these hazard ratios substantially. Genotype did not predict risk in men. Finally, results for IHD were borderline significant ( P =0.06) in an independent case–control study including 933 patients and 8068 controls. Conclusion This is the first study to suggest that ZNF202 could be a new candidate gene for IHD and MI in the general population. |
| Databáze: | OpenAIRE |
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