The effect of ketotifen on density distribution of eosinophils in patients with atopic dermatitis

Autor:	Kayoko Iryo, Yoichiro Sasai, Mamoru Kasada, Shingo Tsuda, Minoru Miyasato
Rok vydání:	1988
Předmět:	Ketotifen Pathology medicine.medical_specialty business.industry Degranulation Clinical manifestation Atopic dermatitis medicine.disease Density distribution Density analysis medicine In patient business After treatment medicine.drug
Zdroj:	Ensho. 8:260-262
ISSN:	1884-4006 0389-4290
DOI:	10.2492/jsir1981.8.260
Popis:	Density analysis and ultrastructural observation were performed on eosinophils from patients with atopic dermatitis (AD) . Before treatment, density analysis displayed lower peak density and greater number of hypodense eosinophils compared with normal subjects. After treatment with ketotifen, profiles demonstrated similar peak density to normal subjects following decreased number of hypodense eosinophils which was directly proportional to remission of clinical symptoms. Hypodense eosinophils were morphologically characterized by partial or complete degranulation. It is suggested that hypodense eosinophils may contribute clinical manifestation of AD and that ketotifen may give clinical remission for patients with AD by decreasing such cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4d91d3d0b02c650a71867265b88db477 https://doi.org/10.2492/jsir1981.8.260 Zobrazit plný text záznamu