An efficient strategy for the large-scale synthesis of head-to-tail cyclic peptides

Autor:	Annette Marian Doherty, Wayne L. Cody, John X. He
Rok vydání:	1994
Předmět:	chemistry.chemical_classification BQ-123 chemistry.chemical_compound Chemistry Stereochemistry Hexafluorophosphate Pharmacology toxicology Biochemistry Combinatorial chemistry Cyclic peptide
Zdroj:	Letters in Peptide Science. 1:25-30
ISSN:	1573-496X 0929-5666
Popis:	An efficient and generally applicable method for the synthesis of head-to-tail cyclic peptides with HBTU (2-(1H-benzotriazol-1-yl)-1,1,3, 3-tetramethyluronium hexafluorophosphate) has been developed. The utility of this approach was exemplified with the multigram preparation of a potent endothelin receptor-selective (ETA) antagonist BQ-123 (cyclo[-d-Trp-d-Asp-Pro-d-Val-Leu-]). This methodology can be readily applied to the small-and largescale synthesis of other head-to-tail cyclic peptides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4d90728efefdb6d9938154467b7ca324 https://doi.org/10.1007/bf00132759 Zobrazit plný text záznamu Full text from SpringerLink