Carotid intima media thickness decreases after pancreas transplantation1
| Autor: | John P. Leone, Christopher Colling, Elizabeth Lyden, Lynn Mack-Shipman, James T. Lane, Melissa Loseke, Judi Erickson, Thomas G. Lynch, Tab W. Burkman, Tanaporn Ratanasuwan, Jennifer L. Larsen, Suzanne A. Miller |
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| Rok vydání: | 2002 |
| Předmět: |
Transplantation
medicine.medical_specialty Type 1 diabetes Creatinine business.industry medicine.disease chemistry.chemical_compound Endocrinology High-density lipoprotein Blood pressure chemistry Intima-media thickness Internal medicine Diabetes mellitus cardiovascular system medicine Cardiology cardiovascular diseases business Macrovascular disease |
| Zdroj: | Transplantation. 73:936-940 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/00007890-200203270-00019 |
| Popis: | Background. Pancreas transplantation (PTX) improves diabetic microvascular complications, but it is unknown whether PTX alters macrovascular disease. Carotid intima media thickness (IMT) has been shown to correlate with cardiovascular events, so this study was designed to evaluate changes in carotid IMT after PTX. Methods. Four groups were studied: PTX candidates (n=60); successful PTX recipients (n=89; mean time since PTX=4.0±0.3 years); patients with type 1 diabetes but without nephropathy (n=20); and normal controls (n=32). Mean IMT and mean of maximum carotid IMT measurements (mean-max IMT), hemoglobin A1C, serum creatinine, body mass index (BMI), blood pressure, smoking status, use of hypolipidemic medications, and fasting lipids were determined in all groups. Results. Age, gender distribution, and BMI were not different among the groups. Duration of diabetes was also equal between pre- and post-PTX groups. Mean and mean-max IMT were greatest pre-PTX and decreased after PTX (P |
| Databáze: | OpenAIRE |
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