Lung adenocarcinoma with type II pneumocyte characteristics

Autor:	S Tsutahara, N Shijubo, M Hirasawa, Y Honda, M Satoh, Y Kuroki, T Akino
Rok vydání:	1993
Předmět:	Pulmonary and Respiratory Medicine
Zdroj:	European Respiratory Journal. 6:135-137
ISSN:	1399-3003 0903-1936
DOI:	10.1183/09031936.93.06010135
Popis:	We report a case of primary lung adenocarcinoma with type II pneumocyte characteristics. Electron microscopic examination demonstrated that the tumour cells had well-developed microvilli and cytoplasmic lamellar inclusion bodies. These ultrastructural features are similar to those seen in type II pneumocytes of normal lung tissue. Western blot analysis, using monoclonal antibody against human surfactant protein A (SP-A), clearly demonstrated that the tumour cells expressed human SP-A, which is a major pulmonary surfactant protein produced by type II pneumocytes. These observations suggest that the tumour was derived from a type II pneumocyte.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4d83f74a59fd15541152915443c13b31 https://doi.org/10.1183/09031936.93.06010135 Zobrazit plný text záznamu