Extraction solvent-dependent antioxidant activities and cancer cell growth inhibitory effects of Scutellaria baicalensis extracts
| Autor: | Mi Jeong Lim, Joo-Heon Hong, Yul Ri Gu |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Korean Journal of Food Preservation. 26:566-575 |
| ISSN: | 2287-7428 1738-7248 |
| DOI: | 10.11002/kjfp.2019.26.5.566 |
| Popis: | This study was conducted to examine the antioxidant activities and cancer cell growth inhibitory effects of Scutellaria baicalensis extracts based on extraction solvent. The yield by hot water extraction (42.56%) was higher than those by extraction with 80% ethanol (19.47%) and 80% methanol (19.57%). The total phenolic and total flavonoid contents in the methanol extract were 26.44 g/100 g and 4.23 g/100 g, respectively. The oxygen radical absorbance capacity of the methanol extract (100 μg/mL) was 274.23 μM, which was significantly higher than those of the other extracts. The DPPH and ABTS radical scavenging activities of the methanol extract (1,000 μg/mL) were 88.71% and 85.05% respectively, while the ferric reducing antioxidant power and reducing power were 110.14 μM and 1.01 respectively. The protective effects against oxidative stress in L132 cells imparted by the methanol extract was better than those imparted by the other extracts. The production of nitric oxide in the methanol extract decreased in a dose-dependent manner. The antitumor activities of the methanol extract (500 μg/mL) in SNU719, A549 and HT29 was cell lines were 75.99%, 61.43% and 67.01% respectively. This study suggests that Scutellaria baicalensis extracts may be useful functional components. |
| Databáze: | OpenAIRE |
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