Evaluation of Renal Biopsies for BK Virus Nephropathy in Non-Renal Transplant Immunosuppressed Patients
| Autor: | Zafer Ercan, Basol Canbakan, Rahmi Yilmaz, Ozgur Merhametsiz, Ebru Gok Oguz, Yunus Erdem, Tolga Yildirim, Ozlem Yayar, Dilek Ertoy Baydar, Deniz Ayli |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.diagnostic_test business.industry Urology medicine.medical_treatment Acute kidney injury Glomerulonephritis Immunosuppression Malignancy medicine.disease Gastroenterology Organ transplantation Transplantation 03 medical and health sciences 030104 developmental biology Internal medicine Biopsy medicine Surgery Renal biopsy business |
| Zdroj: | Turkish Nephrology Dialysis Transplantation. 25:162-167 |
| ISSN: | 1300-7718 |
| Popis: | Correspondence Address: Ebru GOk Oguz Diskapi Yildirim Beyazit Egitim ve Arastirma Hastanesi, Nefroloji Bolumu, Ankara, Turkey Phone : + 90 312 341 03 00 E-mail : ebrugokoguz@hotmail.com Received : 01.11.2015 Accepted : 21.11.2015 ABstrACt OBJeCtIVe: Although BK virus nephropathy (BKVN) has mostly been reported to occur in transplanted kidneys, there has been a gradual increase in cases of BKVN in the native kidney. This study was directed towards investigating the incidence of BKVN in patients undergoing renal biopsy due to acute kidney injury (AKI) who were also immunosuppressed due to a condition other than organ transplantation. MAterIAl and MethOds: Out of the 1223 patients undergoing renal biopsy for various conditions between January 2001 and January 2013, 52 patients who underwent a biopsy for AKI and were immunosuppressed at the time of the biopsy were included into the study. After renal biopsies of all patients were reevaluated, all biopsy specimens were exposed to immunohistochemical staining for SV40 antibody. results: Of the 52 patients, 29 had primary glomerulonephritis, 18 had secondary glomerulonephritis and 5 had a malignancy. All patients except one case of acute lymphoblastic leukemia and one case of non-Hodgkin lymphoma were immunosuppressed due to immunosuppressive therapy. None of the patients had any signs of BKVN on immunohistochemical staining of renal biopsy specimens. COnClusIOn: Failure to detect BKVN in this study may be because BKV causes gradual impairment of renal functions and the sample did not include patients frequently observed to have BKVN in the native kidney. keY wOrds: Acute kidney injury, BK virus nephropathy, Immunosuppression, Renal biopsy, Renal transplantation, SV40 antibody |
| Databáze: | OpenAIRE |
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