Dietary pattern regulates fatty acid desaturase 1 gene expression in Indian pregnant women to spare overall long chain polyunsaturated fatty acids levels
| Autor: | Suhas Otiv, Kalpana Joshi, Kumar S.D. Kothapalli, Maithili S. Gadgil, Anand Pandit, J. Thomas Brenna |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification medicine.medical_specialty biology FADS1 FADS2 Linoleic acid General Medicine Eicosapentaenoic acid 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Fatty acid desaturase Endocrinology chemistry Docosahexaenoic acid 030220 oncology & carcinogenesis Internal medicine Genetics biology.protein medicine Arachidonic acid Molecular Biology Polyunsaturated fatty acid |
| Zdroj: | Molecular Biology Reports. 46:687-693 |
| ISSN: | 1573-4978 0301-4851 |
| DOI: | 10.1007/s11033-018-4524-x |
| Popis: | The aim of this study was to determine if the dietary pattern of pregnant women has any compensatory effect on the fatty acid desaturase (FADS) gene expression, thus enhancing the conversion of precursors to long chain polyunsaturated fatty acids (LCPUFA) to spare the overall LCPUFA levels. The dietary intake of plant-based precursor polyunsaturated fatty acids (PUFA) influences circulating levels of LCPUFA. We hypothesized that low LCPUFA diets during pregnancy would compensate by higher expression of FADS genes to enhance the conversion of precursors to LCPUFA to spare the overall LCPUFA levels. Seventy-five pregnant women were enrolled during the last trimester of pregnancy based on the eligibility and exclusion criteria. Maternal LCPUFA in plasma, expression of FADS1 and FADS2 genes, FADS2 Indel genotype status and neonate birth weight were studied.In the vegetarian group (n = 25), plasma α-linolenic acid (ALA) but not linoleic acid (LA) was significantly lower (p |
| Databáze: | OpenAIRE |
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