Chronic Rhinosinusitis in Pediatric Immunodeficiency
| Autor: | Maria Garcia-Lloret, Monica Tsai, Alex Wonnaparhown, Manish J. Butte |
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| Rok vydání: | 2020 |
| Předmět: |
business.industry
Common variable immunodeficiency Medicine (miscellaneous) Context (language use) Disease medicine.disease 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Chronic granulomatous disease 030228 respiratory system Immunity DiGeorge syndrome Immunology medicine Primary immunodeficiency Immunology and Allergy business Immunodeficiency |
| Zdroj: | Current Treatment Options in Allergy. 7:219-232 |
| ISSN: | 2196-3053 |
| DOI: | 10.1007/s40521-019-00230-1 |
| Popis: | Chronic rhinosinusitis and other sinopulmonary infections can be a hallmark of impaired immunity in children. Rhinosinusitis in the setting of immunodeficiency can often be chronic and refractory, and involve opportunistic pathogens. We review the evaluation and management of pediatric chronic rhinosinusitis in the context of primary immunodeficiency diseases. Immunodeficiencies found to be associated with chronic rhinosinusitis include common variable immune deficiency, X-linked agammaglobulinemia, antibody deficiencies, hyper-IgM syndrome, hyper-IgE syndrome, Wiskott–Aldrich syndrome, activated PI3K disease, DiGeorge syndrome, and chronic granulomatous disease. Chronic rhinosinusitis in children may be a clinical manifestation of immunodeficiency. The evaluation and diagnosis of immunodeficiencies are essential for initiating appropriate therapeutic strategies, including antibiotics, prophylaxis, topical therapy, surgery, and immunoglobulin replacement. |
| Databáze: | OpenAIRE |
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