Synthesis of 1,3-Disubstituted Ureas Containing Cycloheptyl or Bicyclo[2.2.1]heptyl Fragments, as Soluble Epoxide Hydrolase Inhibitors

Autor:	V. S. D’yachenko, A. A. Vernigora, E. V. Rasskazova, V. V. Burmistrov, Gennady M. Butov
Rok vydání:	2019
Předmět:	Epoxide hydrolase 2 Heptane Bicyclic molecule 010405 organic chemistry Chemistry Organic Chemistry 01 natural sciences 2-Norbornyl cation 0104 chemical sciences chemistry.chemical_compound Lipophilicity Urea Molecule Organic chemistry Cycloheptane
Zdroj:	Russian Journal of Organic Chemistry. 55:1136-1144
ISSN:	1608-3393 1070-4280
Popis:	To assess the effect of the lipophilicity of different parts of urea molecules on their activity as soluble epoxide hydrolase inhibitors, a series of 1,3-disubstituted ureas containing cycloheptane and bicyclo-[2.2.1]heptane fragments were prepared by the reaction of isocyanates with corresponding amines in 78–94% yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4d6a871d857f9ac5c221b8187ca703f7 https://doi.org/10.1134/s1070428019080128 Zobrazit plný text záznamu Plný text ve formátu PDF