Mechanism of Thymineless Death

Autor: Bruce M. Bleile, Mehran Goulian, Robert H. Grafstrom, Scott A. Neynaber, Ben Y. Tseng, Lisa M. Dickey, Mark S. Peterson, Holly A. Ingraham
Rok vydání: 1986
Předmět:
Zdroj: Purine and Pyrimidine Metabolism in Man V ISBN: 9781468412505
DOI: 10.1007/978-1-4684-1248-2_15
Popis: Approximately 30 years ago it was observed by Seymour Cohen that an E. coli mutant that required thymine became non-viable within one generation time after transfer to a medium lacking thymine. This was in contrast to the prolonged tolerance for depletion of precursors for protein or RNA synthesis, or requirements for energy metabolism and carbon sources.
Databáze: OpenAIRE