Enantioselective β-C(sp3)–H arylation of amidesviasynergistic nickel and photoredox catalysis

Autor:	Xiaomin Shu, Wu Zhang, Haohua Huo, Leitao Huan, Buqing Cheng
Rok vydání:	2021
Předmět:	Nickel Chemistry Yield (chemistry) Organic Chemistry Enantioselective synthesis Photoredox catalysis chemistry.chemical_element Physical and Theoretical Chemistry Cleavage (embryo) Biochemistry Medicinal chemistry
Zdroj:	Organic & Biomolecular Chemistry. 19:9407-9409
ISSN:	1477-0539 1477-0520
DOI:	10.1039/d1ob01774h
Popis:	An enantioselective benzylic β-C(sp3)–H arylation of amides via synergistic nickel and photoredox catalysis is reported. The C–H bond is activated by a bromine-radical-mediated C–H cleavage. This mild yet straightforward protocol provides arylation products in up to 96% yield and with up to 95% ee.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4d647dcd5c4530333414ada36c91cb3d https://doi.org/10.1039/d1ob01774h Zobrazit plný text záznamu