Comment se comparent néphrectomies partielles et élargies pour le traitement des carcinomes papillaires pT1aN0M0 ? Étude comparative rétrospective de 277 cas
| Autor: | Nathalie Rioux-Leclercq, Arnaud Mejean, J-C. Bernhard, Maxime Crepel, Jacques Tostain, Laurent Zini, B. Albouy, Karim Bensalah, J.J. Patard, Allan J. Pantuck, A. De La Taille, Pierre Bigot, Vincenzo Ficarra, S.F. Shariat, Arie S. Belldegrun, A. Villers, Jean-Marie Ferriere, L. Salomon, A.-R. Azzouzi, Marc Colombel, F. Montorsi, C. Pfister |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Treated group Tumor size business.industry Urology medicine.medical_treatment 030232 urology & nephrology Nephrectomy 3. Good health Surgery Log-rank test 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis medicine Nephron sparing surgery Stage (cooking) Nuclear medicine business Survival rate Survival analysis |
| Zdroj: | Progrès en Urologie. 20:350-355 |
| ISSN: | 1166-7087 |
| DOI: | 10.1016/j.purol.2010.01.007 |
| Popis: | PURPOSE: Our objective was to compare oncologic results of nephron sparing surgery (NSS) versus radical nephrectomy (RN) in T1aN0-x M0 papillary renal cell carcinoma (PRCC). PATIENTS AND METHODS: We retrospectively reviewed 277 patients treated for a pT1aN0M0 PRCC selected from an academic database from 12 centres. We compared the clinico-pathological features by using Chi-square and Student statistical analyses. Survivals analyses using Kaplan-Meier and Log-rank models were performed. RESULTS: The two groups were composed by 186 patients treated by NSS and 91 by RN. The TNM stage was fixed and the two groups were, in terms of age and Fuhrman grade, comparable. Median age at diagnosis was 59 years (27-85). Median tumor size was 2.7 cm (0.4-4). The average follow-up was 49 months (1-246). Very few events arose in both groups: two local recurrences were observed in the NSS group (1.07%), three patients died of cancer in the NSS treated group (1.6%) and five in the RN treated group (5.5%). The five and 10 cancer-specific survival rate were comparable in the two groups (98% vs. 100% and 98% vs. 97%). The specific survival curves were perfectly similar for both groups (log rank test, p=0.25). CONCLUSION: NSS is equivalent to RN as far as oncologic control of pT1aN0M0 PRCC is concerned. |
| Databáze: | OpenAIRE |
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