The enantioselective synthesis of an important intermediate to the antiviral, (–)-carbovir

Autor:	Robert J. Pryce, John E. Hawes, Sheetal Handa, Jeremy Hallam Shears, Phillip J. Geary, George Ryback, Gareth Thomas Phillips, George J. Earlam
Rok vydání:	1994
Předmět:	Stereochemistry medicine.drug_class Enantioselective synthesis Carboxamide Enzyme catalysis chemistry.chemical_compound Hydrolysis Aminolysis chemistry Amide polycyclic compounds medicine Organic chemistry Enantiomer Enantiomeric excess
Zdroj:	J. Chem. Soc., Perkin Trans. 1. :1885-1886
ISSN:	1364-5463 0300-922X
DOI:	10.1039/p19940001885
Popis:	Two new routes to the important intermediate (–)-8 for the carbocyclic-based nucleosides are reported. The intermediate (–)-8 has also been synthesised in high. Enantiomeric excess via an enzymatic resolution of the racemic amide (+)-8 or an enzymatic enantiotopic hydrolysis of the meso diester 12.
Databáze:	OpenAIRE
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