Analysis of the milling rate of pharmaceutical powders using the Distinct Element Method (DEM)
| Autor: | A. Craig Bentham, Dimitris Papadopoulos, C.C. Kwan, Yong Qi Chen, Hiroshi Mio, Fumio Saito, Yulong Ding, Mojtaba Ghadiri |
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| Rok vydání: | 2005 |
| Předmět: |
Materials science
Applied Mathematics General Chemical Engineering Mineralogy General Chemistry First order Industrial and Manufacturing Engineering Discrete element method Microcrystalline cellulose chemistry.chemical_compound Reaction rate constant chemistry Composite material Material properties Ball mill |
| Zdroj: | Chemical Engineering Science. 60:1441-1448 |
| ISSN: | 0009-2509 |
| Popis: | The milling behaviour of microcrystalline cellulose (MCC) and αα-lactose monohydrate (ααLM) in an oscillatory single ball mill has been analysed by using the Distinct Element Method (DEM). The experimental results suggest that the milling behaviour of ααLM is more strongly influenced by the milling frequency as compared to MCC. A similar conclusion is also drawn from the DEM results. The milling behaviour of MCC and ααLM is described by a first order rate process, and its rate constant, K pp, is found to correlate very well with the milling power, P nn, determined by the DEM simulation, except for the milling behaviour of ααLM at 18 Hz. For the latter, there appears to be an incubation time after which the milling rate increases substantially. The results presented here provide a basis for predicting the milling behaviour of a material systematically based on the fundamental material properties and the machine dynamics without the need for extensive experiment and use of large quantities of materials. |
| Databáze: | OpenAIRE |
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