The role of complement anaphylatoxin receptors in mesenteric ischemia/reperfusion-induced injury

Autor:	Stephen M. Taylor, Helga D. Manthey, Mike C. L. Wu, Tyson A. Moore, Trent M. Woodruff
Rok vydání:	2010
Předmět:	business.industry Anaphylatoxin receptors Immunology Ischemia chemical and pharmacologic phenomena Inflammation medicine.disease Complement system Complement (complexity) Pathogenesis Medicine Anaphylatoxin medicine.symptom business Receptor Molecular Biology
Zdroj:	Molecular Immunology. 47:2270-2270
ISSN:	0161-5890
DOI:	10.1016/j.molimm.2010.05.216
Popis:	Inflammation is a major driver of pathology in ischemia reperfusion (IR) injuries. The complement activation products complement anaphylatoxin 3a (C3a) and complement anaphylatoxin (C5a), are powerful pro-inflammatory mediators which activate inflammatory cells and the release of pro-inflammatory substances involved in the pathology of IR. We are currently exploring the role of the anaphylatoxin receptors using mice deficient in these receptors (CD88, C5L2, and C3aR). This study demonstrates a role for complement activation, C5a generation and CD88 activation in the pathogenesis of intestinal IR injury in mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4d3d7e014a0c16f719d837f7ffbaf692 https://doi.org/10.1016/j.molimm.2010.05.216 Zobrazit plný text záznamu Full Text from ScienceDirect