Dimeric Ecdysteroid Analogues and Their Interaction with the Drosophila Ecdysteroid Receptor

Autor:	Juraj Harmatha, Karel Vokáč, Miloš Buděšínský, Laurence Dinan, René Lafont
Rok vydání:	2006
Předmět:	Ecdysteroid biology Stereochemistry Dimer 20-Hydroxyecdysone Infrared spectroscopy General Chemistry Nuclear magnetic resonance spectroscopy biology.organism_classification chemistry.chemical_compound chemistry Bioassay Drosophila (subgenus) Receptor
Zdroj:	Collection of Czechoslovak Chemical Communications. 71:1229-1238
ISSN:	1212-6950 0010-0765
Popis:	Three structurally related specific ecdysteroid derivatives, 7,7'-dimers of 14-deoxy-8(14)-ene transformed 20-hydroxyecdysone, ponasterone A and ajugasterone C, were obtained by photochemical transformation. The structures of the dimeric ecdysteroids were identified mainly by NMR spectroscopy supported by MS and IR spectroscopy. Yields of the dimerisation products were dependent on the reactant concentrations and photoreaction conditions. Inert gas atmosphere supported high yields, whereas oxygen atmosphere fully prevented the dimer formation. All the three dimers retained a rather high agonistic activity at the ecdysteroid receptor in the Drosophila BII bioassay when compared with the relevant original ecdysteroids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4d37fb22c5364ea8435e4b8f40320e6d https://doi.org/10.1135/cccc20061229 Zobrazit plný text záznamu